A collection of nine offprints detailing their work which led to their winning the Nobel Prize in medicine in 1965 "for their discoveries concerning genetic control of enzyme and virus synthesis.”
[Various places and publications, 1961-1965]. Includes the following offprints: 1. JACOB, François, and Jacques Monod. “On the Regulation of Gene Activity.” Reprinted from Cold Spring Harbor Symposia on Quantitative Biology, Volume XXVI, 1961, pp. 193-211; 2. MONOD, Jacques, and François Jacob. “General Conclusions: Teleonomic Mechanisms in Cellular Metabolism, Growth, and Differentiation.” Reprinted from Cold Spring Harbor Symposia on Quantitative Biology, Volume XXVI, 1961, pp. 389-401; 3. JACOB, François, and Jacques Monod. “Determinisme et regulation specifique de la synthèse des proteines.” Reprinted from “Proceedings of the Fifth International Congress of Biochemistry,” Volume I, Pergamon Press, 1963. pp. [132]-154l; 4. JACOB, François, and Jacques Monod. “Genetic Repression, Allosteric Inhibition, and Cellular Differentiation. Reprinted from Cytodifferential & Macromolecular Scynthesis, New York: Academic Press Inc., 1963. pp. [30]-64; 5. MONOD, Jacques, Jean-Pierre Changeux, and François Jacob. “Allosteric Proteins and Cellular Control Systems.” Reprinted from the Journal of Molecular Biology, Volume 6 (1963), pp. 306-329. All ten papers are in excellent condition. Item #18040
Also includes: 6. JACOB, François, Sydney Brenner, and François Cuzin. “On the Regulation of DNA Replication in Bacteria.” Reprinted from Cold Spring Harbor Symposia on Quantitative Biology, Volume XXVIII, 1963, pp. 329-348;7. JACOB, François, and Jacques Monod. “Mécanismes biochimiques et génétiques de la régulation dans la cellule bactérienne.” Reprinted from Bulletin de la Société de Chimie biologique, Extrait du Tome XLVI, No. 12, 1964, pp. 1499-1532; 8. MONOD, Jacques, Jeffries Wyman, and Jean-Pierre Changeux. “On the Nature of Allosteric Transitions: A Plausible Model.” From the Journal of Moleculary Biology, Volume 12 (1965), pp. 88-118; and 9. JACOB, François, A. Ullmann, and J. Monod. “Délétions fusionnant l’Opéron Lactose et un Opéron Purine chez Escherichia coli.” Reprinted from the Journal of Molecular Biology, Volume 13 (1965), pp. 704-719. Also with an extra paper by Jean-Pierre CHANGEUX, collaborator of François Jacob and Jacques Monod: Effet des Analogues de la L-Thréonine et de la L-Isoleucine sur la L-Thréonine Désaminase.” Reprinted from the Journal of Molecular Biology, pp, 220-255. December, 1961.
An important chapter in the story of the discovery of the structure and function of DNA involves the work done by François Jacob, Jacques Monod, Andre Lwoff, and their associates, culminating in the 1965 Nobel Prize for medicine and physiology. In 1957, Jacob began collaborating with Jacques Monod (1910-76). Together, the two French scientists showed how the genetic information contained in DNA can be switched on and off—the “operon” theory of gene regulation that lies at the heart of our modern conception of the genetic control of embryonic development. Then, with Sidney Brenner and Mathew Meselson, Jacob isolated Messenger RNA, the molecule which transcribes the coded information of DNA and then serves as the template for this information’s translation into proteins. One of most important contributions of Monod and Jacob was their development of the theory of allosteric proteins—proteins containing two or more topologically distinct binding sites which interact functionally with each other. The two papers included here (Numbers 5 and 8) introduce that theory. Monod’s and Jacob’s ideas in this area were very influential to the later work of Francis Crick (who called allostery “an extremely powerful idea”) and Max Perutz. See the lengthy discussion by Judson in The Eighth Day of Creation, pp. 552-5.
Price: $4,500.00